Lyophilized Powder Vials, Serum Ampoules, Oral Liquid Bottles & Enzyme Bottles
yophilized powder vials
Serum ampoules
Oral liquid bottles
Enzyme bottles
Type I borosilicate
RTD · USP/EP
- Fast Delievery
- Quality Assurance
- 24/7 Customer Service
Full Customization
Description
--- LYOPHILIZATION · PHARMACEUTICAL CONTAINERS · RTD
Lyophilized
Powder Vials
& Pharmaceutical
Containers
Type I borosilicate · USP/EP · Lyo optimised · RTD
A complete pharmaceutical container portfolio - lyophilized powder vials, serum ampoules, oral liquid bottles, and enzyme bottles - engineered to the thermal and structural demands of freeze-drying, sterile filling, and long shelf-life storage. Ready-to-deliver components with full validation documentation.
Lyophilized powder vials
Serum ampoules
vial rubber stoppers
vial caps
Oral liquid bottles
Enzyme bottles
Type I borosilicate
RTD · USP/EP
Lyophilized Powder Vials
Type I · Lyo optimised
Serum Ampoules
Sealed · clear & amber
Oral Liquid Bottles
PP · food & pharma grade
Enzyme Bottles
Low-extractable · stable
Products range
Four container families. One supplier.
From freeze-dryer shelf to hospital shelf - our container range covers every stage and form factor in the pharmaceutical container lifecycle. All four product families are available with full validation documentation and factory-direct pricing.
Type I borosilicate · Lyo optimised · RTS/RTD · USP/EP
Depyrogenated Type I borosilicate glass vials engineered specifically for freeze-drying applications. The flat bottom geometry maximises contact area with the lyophilizer shelf surface - optimising heat transfer efficiency throughout the freezing and primary drying cycles. Available in standard pharmaceutical sizes matched to common lyo equipment tray configurations. Supplied washed, depyrogenated, and ready-to-deliver.
Type I borosilicate, Lyo optimised, Flat bottom, Depyrogenated, RTD · RTS, USP · EP
1–30 mL · Clear & amber · GMP · ISO15378
Precision-drawn borosilicate glass ampoules for pharmaceutical and cosmetic serums, injectables, and high-value biological preparations. Available in clear (maximum optical transparency for visual inspection) and amber (UV filtration below 470 nm for light-sensitive formulations). Inner packaging in plastic or paper box with heat-shrinkage film; outer packaging in strong corrugated carton with pallet option for large orders.
1–30 mL, Clear · Amber, GMP, ISO 15378, ISO 9001, ISO 14001
25 · 30 · 50 mL · Food & pharmaceutical grade PP
Food-grade and pharmaceutical-grade polypropylene (PP) oral liquid bottles for enzyme drinks, collagen preparations, syrup dispensing, and functional supplement packaging. Heat-resistant up to 120 °C - compatible with hot-fill and pasteurisation processes. BPA-free construction with airtight screw cap closure. Custom colours, OEM printing, and custom volumes available factory direct.
25 · 30 · 50 mL, PP food grade, Heat resistant, BPA free, OEM custom
Borosilicate · Low extractables · Stable across pH 2–12
Type I borosilicate glass vials and ampoules for enzyme solutions, biological reagents, and biotech liquid formulations. The chemically inert glass surface minimises non-specific protein adsorption and enzyme activity loss - critical for enzymatic preparations where container-to-product interaction must be controlled. Amber glass options available for light-sensitive enzyme formulations including peroxidases, photolyases, and carotenoid-containing preparations.
Type I borosilicate, Low extractables, pH 2–12 stable, Amber available, Low adsorption
Lyophilization is the most demanding environment a pharmaceutical container ever encounters. Sub-zero temperatures, deep vacuum, thermal cycling between −60 °C and +40 °C, and in-situ mechanical stoppering - every vial specification decision directly impacts process efficiency, product quality, and cycle time
Bottom geometry & heat transfer
Shelf contact · thermal efficiency
The heat transfer rate between the lyophilizer shelf and the vial determines both the freezing uniformity and the primary drying rate. Our lyophilisation vials feature a flat, optically polished bottom surface - maximising the contact area between glass and shelf metal, and minimising the thermal resistance at the interface.
Flat bottom - maximum shelf contact area
Controlled bottom thickness for uniform Kv (heat transfer coefficient)
Consistent glass wall thickness → uniform sublimation front
Compatible with PAT (Process Analytical Technology) shelf temperature monitoring
Thermal cycling resistance
−60°C to +60°C · no microcracking
A complete lyophilization cycle subjects the vial to multiple thermal transitions - filling at room temperature, rapid freezing to −50 °C, primary drying at −25 to −40 °C, and secondary drying ramping up to +20–40 °C. Type I borosilicate glass provides exceptional thermal shock resistance throughout this range without microcracking or container integrity failure.
Borosilicate CTE: ~3.3 × 10⁻⁶/°C - one of the lowest of any glass
Validated for repeated −60°C to +60°C thermal cycling
No microcracking under standard lyo cycle thermal profiles
Vacuum integrity under ≤ 20 Pa
Container closure · deep vacuum
The container must maintain structural integrity and be compatible with the in-situ stoppering process under chamber pressures as low as 20 Pa (0.2 mbar). The vial neck geometry and tolerances are specified to accept the lyo stopper smoothly during in-situ stoppering - without requiring excessive mechanical force that could cause vial breakage or stopper misalignment.
Neck dimensions toleranced for lyo stopper compatibility
Dimensionally stable under ≤ 20 Pa vacuum
Smooth neck finish for controlled stopper insertion force
In-situ stoppering compatibility
Hydraulic shelf press · controlled atmosphere
The in-situ stoppering mechanism presses all shelves together simultaneously under vacuum or nitrogen backfill - the most critical mechanical event in the lyo cycle. Our vials are manufactured with tight neck height and outer diameter tolerances to ensure every stopper seats fully and uniformly in a single press cycle, eliminating partially-seated stopper defects.
Neck height ±0.2 mm tolerance for uniform stoppering
Compatible with all major lyo equipment manufacturers
N₂ or inert gas backfill compatible
Chemical inertness during freeze-dry
No leaching · no pH shift
During lyophilization, the drug product is in extended contact with the vial in both liquid and solid states. Type I borosilicate glass has the lowest hydrolytic extractables of any pharmaceutical glass type - the freezing process does not increase extraction rates beyond those observed at ambient temperature, and no pH shift is introduced by glass dissolution.
Hydrolytic class I - lowest extractables of any glass type
No pH shift from glass leaching throughout lyo cycle
Stable for biologics, mAbs, vaccines, and peptides
Depyrogenation & validation docs
≥300°C · LRE ≥3 log · USP/EP
Vials are supplied depyrogenated by dry-heat tunnel at ≥ 300 °C, achieving a minimum 3-log endotoxin reduction (LRE ≥ 3) compliant with USP <1211> and EP 5.1.1. Depyrogenation validation data, temperature mapping records, and Certificate of Analysis are available for every lot to support your process qualification documentation package.
≥ 300 °C dry-heat depyrogenation - LRE ≥ 3-log
USP <1211> and EP 5.1.1 compliant
CoA + validation package per lot
RECOMMENDED COMPANION STOPPERS
Complete the system - matching lyo stoppers
Every vial needs a stopper. For lyophilization vials, the stopper is not an afterthought - it is a critical component that must be dimensionally matched to the vial neck and designed for the specific demands of the freeze-drying cycle.
Auto-recommended - based on your vial selection
The stoppers below are selected to match the 20 mm vial neck diameter of our lyophilisation vials. If you are ordering a different vial neck size (13 mm or other), contact us for a matched stopper recommendation. Using a correctly sized stopper prevents insertion force failures and ensures reliable in-situ stoppering during the lyo cycle.
20 mm Pre-Washed Lyophilisation Stopper
Recommended for lyo vials,
Matched to 20 mm lyo vials
5-slot vent · Bromobutyl · Washed · Autoclave-ready · Bag of 1,000
The standard lyo stopper for 20 mm vial neck. Five vent slots allow moisture and vapour to escape from the vial headspace during primary and secondary drying while the stopper sits partially inserted. Manufactured from bromobutyl rubber for low gas permeability and low extractables. Pre-washed and supplied in bags of 1,000 pieces - inner autoclave-compatible bag + outer PE bag with lot labelling. Customer autoclave sterilisation required before use. Independent third-party endotoxin and bioburden testing completed.
EO or gamma sterilised · RTU · Sealed sterile bag · On request
Pre-sterilised RTU option
The same 20 mm 5-slot bromobutyl lyophilisation stopper supplied in a pre-sterilised, ready-to-use configuration - in a sealed sterile bag that can be opened directly at your filling line without a customer autoclave step. Sterilisation method (ethylene oxide or gamma irradiation) confirmed at order stage based on your drug product compatibility requirements. Same independent third-party endotoxin and bioburden test data, same lot documentation. Contact us to specify this option at order stage.
QUICK COMPARISON
All four container families - at a glance
A cross-reference of key specifications across the four product lines to help you identify and qualify the right container for your application.
| Container | Material | Key sizes | Primary application | Special feature |
|---|---|---|---|---|
| Lyophilized powder vials | Type I borosilicate glass | 2–100 mL (custom) | Freeze-drying, biologics, vaccines | Flat bottom, depyrogenated, lyo stopper compatible |
| Serum ampoules | Type I borosilicate glass | 1–30 mL | Injectable serums, cosmetics, biologics | Clear & amber, sealed flame-tip, heat-shrink inner pack |
| Oral liquid bottles | Pharmaceutical / food grade PP | 25, 30, 50 mL (custom) | Enzyme drinks, collagen, syrup, supplement | Heat resistant 120 °C, BPA free, OEM colour/print |
| Enzyme bottles | Type I borosilicate glass | 2–50 mL | Enzyme solutions, biotech reagents | Low adsorption surface, amber for light-sensitive |
Glass grade
Borosilicate · lowest extractables
Type I
Ready-to-deliver
Washed · depyrogenated · validated
RTD
Depyrogenation
LRE ≥3 log · USP/EP compliant
≥300°C
Container families
Vials · ampoules · oral · enzyme
04
Factory direct
Validation docs · CoA · bulk pricing
05
From freeze-dryer shelf
to patient. Every container.
Request product samples, validation documentation, or a production quote for any container in our range - lyophilisation vials with matched lyo stoppers, serum ampoules, oral liquid bottles, or enzyme containers. Factory direct, same-day response.
REQUEST SAMPLES & QUOTE
VALIDATION DOCUMENTS
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