Flip Off Cap 20mm With Rubber Stopper
20mm standard size
flip off cap type
bromobutyl stopper
pre-matched, fit confirmed
multi-color, custom options
USP / ISO compliant
- Fast Delievery
- Quality Assurance
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Full Customization
Description
20mm Flip Off Cap with Rubber Stopper · Matched Pair
Multiple Colours · Bulk Supply · USP <381> · ISO 8362
20mm flip off cap with rubber stopper · pharmaceutical vial closure · matched pair · bulk supply
20mm Flip Off Cap
with Rubber Stopper
Matched Pair · Aluminium-Plastic Cap + Bromobutyl Stopper · Multiple Colours · Ready to Crimp
Pre-matched 20mm cap and stopper · confirmed dimensional fit · USP <381> · ISO 8362 · colour-coded options
|
20mm Standard size |
Flip off Cap type |
Bromobutyl Stopper elastomer |
Pre-matched Fit confirmed ★ |
Multi-colour Custom options |
USP/ISO Compliant |
Component specifications - cap and stopper
20mm flip off cap and rubber stopper - what each component is and does
The 20mm flip off cap with rubber stopper is supplied as a pre-matched pair - one aluminium-plastic flip off cap and one 20mm bromobutyl rubber stopper, dimensionally confirmed to work together on the 20mm standard vial neck finish. Each component is specified below.
Aluminium-plastic flip off cap
Al crimp shell + PP flip tab · tamper evident
The 20mm flip off cap consists of an aluminium crimp shell with integrated side skirts that wrap around the vial neck on crimping, and a polypropylene (PP) flip tab on the top surface. The aluminium shell holds the rubber stopper under compression after crimping; the PP flip tab is snapped or flipped off to expose the rubber stopper surface for needle access. Available in a wide range of flip tab colours for product identification.
|
20mm crimp OD |
AL + PP material |
|
custom tab colour |
ISO 8362 standard REF |
bromobutyl rubber stopper
Serum type · 20mm nominal · USP <381>
The 20mm bromobutyl rubber stopper is the primary sealing element - compressed into and against the glass vial neck by the aluminium cap's crimp force to create a hermetic closure. It allows needle penetration for product withdrawal or addition and self-seals after needle withdrawal. The 20mm nominal size is matched to the 20mm vial neck finish as specified in ISO 8362-2 for tubular glass injection vials.
|
20mm nominal size |
bromobutyl elastomer |
|
USP <381> standard |
40-55A hardness |
Why order cap and stopper together as a matched pair
Ordering the 20mm flip off cap and 20mm rubber stopper together as a matched pair from one supplier confirms dimensional compatibility before they reach your facility. The stopper's plug head diameter must seat correctly inside the cap's inner opening; the cap's crimp skirt geometry must apply the right compression force to the stopper against your specific vial neck. When cap and stopper come from the same source and the same batch, these relationships are pre-confirmed - eliminating the compatibility checking that would be required if you sourced them separately.
colour options - flip tab identification
Colour-coded flip tabs - identify your product at a glance
The PP flip tab of the 20mm flip off cap is available in a wide range of colours. Colour coding is widely used in pharmaceutical and clinical settings to differentiate products, dosage strengths, or therapeutic categories at the point of dispensing and administration - reducing product mix-up risk in multi-product environments.
blue
standard
white
standard
pink
standard
red
standard
black
standard
light blue
standard
green
standard
purple
standard
orange
standard
amber
standard
yellow
standard
gold
custom
Custom Pantone or RAL colour matching available on request
Standard stock colours (blue, red, green, amber, white, black, purple, yellow, pink, light blue, orange) are available for orders from standard MOQ. Custom colour matching to a specific Pantone, RAL, or brand colour reference is available for larger order quantities - confirm MOQ and lead time at time of enquiry. Matte and gloss finish options are also available for some colours.
How to use - crimping process overview
From matched pair to sealed vial - the crimping process
The 20mm flip off cap with rubber stopper is applied to a filled vial in a defined sequence. Understanding this process helps confirm that your crimping equipment and settings are appropriate for the closure.
1
Fill the vial with your formulation
Fill the Type 1 borosilicate glass vial with your liquid or powder formulation to the target fill volume, leaving appropriate headspace. The headspace volume is defined by your vial specification and should account for stopper insertion depth - confirm with your vial's dimensional drawing. For aseptic processes, filling takes place under appropriate environmental controls before the stopper is placed.
2
Insert the 20mm rubber stopper into the vial neck
Place the 20mm bromobutyl rubber stopper into the vial neck - the stopper plug head seats into the neck opening and the skirt sits against the outside of the neck finish. The stopper should be seated firmly but is not yet fully sealed - it sits at the neck rather than being pressed to full compression depth, which is achieved by the crimping step. For lyophilization formats, the two-leg stopper is placed partially inserted and fully closed by the lyophilizer shelf before this step.
3
place the 20mm flip off cap over the stopper and neck
Position the 20mm flip off cap over the stoppered vial neck - the cap's crimp shell sits over the stopper head and the cap's skirt rests against the vial neck flange below. At this stage the cap is loose; the crimping tool applies the force that completes the seal.
4
crimp the cap using a calibrated crimping tool
Apply the 20mm crimping tool (manual, semi-automatic, or automatic inline crimper) to the cap - the tool's jaws roll or press the aluminium skirt in and under the vial neck flange, locking the cap in place and compressing the rubber stopper against the glass neck walls. Crimp force settings should be validated for your specific vial, stopper, and cap combination - a calibrated residual seal force (RSF) test on a sample from each batch confirms correct crimp force application.
5
inspect and confirm - the sealed vial is ready
After crimping, visually inspect each vial for correct cap seating (cap sits flat, no visible gap between cap skirt and vial neck), correct crimp geometry (no open crimp segments), and stopper position (no stopper movement visible through the glass). Container closure integrity testing (CCIT) at qualification validates the process; visual inspection at production confirms it is maintained batch by batch.
vial compatibility - which vials work with this cap and stopper
20mm cap and stopper - which vials are compatible
The 20mm flip off cap and matched rubber stopper are compatible with the standard range of 20mm neck finish pharmaceutical injection vials. The table below confirms compatibility by vial type and volume.
| Vial type | Typical volume | 20mm flip off cap | 20mm rubber stopper | Notes |
|---|---|---|---|---|
| Tubular glass serum vial | 5ml – 20ml | ✓ Primary fit | ✓ Standard serum | ISO 8362-2 · most common injectable format |
| Moulded glass injection vial | 5ml – 30ml | ✓ Confirm neck OD | ✓ Confirm neck OD | ISO 8362-1 · confirm 20mm neck finish |
| Lyophilization vial | 5ml – 20ml | ✓ Same cap | Two-leg lyo stopper | Stopper type changes; cap is identical |
| Hormone oil vial | 5ml – 20ml | ✓ Primary fit | ✓ Oil-compatible grade | Confirm elastomer compatibility with carrier oil |
| Multi-dose aqueous vial | 10ml – 20ml | ✓ Primary fit | ✓ Standard serum | Self-sealing performance tested per USP <381> |
| Antibiotic powder vial | 5ml – 15ml | ✓ Same cap | Two-leg or flat-base | Fill process determines stopper type |
| Peptide / biologic vial | 5ml – 20ml | ✓ Primary fit | ✓ Low-extractable grade | Specify low-extractable stopper for biologics |
| 13mm neck vial | 1ml – 5ml | ✗ Wrong size | ✗ Wrong size | Use 13mm cap and stopper instead |
MOQ AND BULK SUPPLY
Order quantities - from sample to full production run
The 20mm flip off cap with rubber stopper is available from sample quantities through to full production run bulk orders. Pricing and lead time scale with quantity.
Tier 1
100
sets
Sample / trial
Free sample available for qualified enquiries. Small trial run for closure validation.
Tier 2
500
sets
Development batch
For process development, validation batches, and clinical supply packaging.
Tier 3
5,000
sets
Standard production
Standard MOQ for commercial production. Single colour per order at this tier.
Tier 4
50,000+
sets
High-volume
High-volume pricing available. Custom colour and labelling options at this tier.
Quantities above are representative - confirm at time of enquiry
MOQ and pricing vary by colour (stock vs custom), stopper grade (standard vs low-extractable), and delivery destination. Mixed-colour orders may require higher minimum quantities per colour. Contact us with your required quantity, colour, stopper grade, and delivery location for a confirmed quotation.
complete specifications
20mm flip off cap with rubber stopper - full specification reference
Reference specifications for the 20mm flip off cap and matched rubber stopper as a pre-confirmed closure pair.
| Parameter | Flip off cap (20mm) | Rubber stopper (20mm) |
|---|---|---|
| Dimensions | ||
| Nominal size | 20mm ★ | 20mm ★ |
| Vial neck compatibility | 20mm neck finish · ISO 8362-2 | 20mm nominal · ISO 8362-5 |
| Materials | ||
| Primary material | Aluminium crimp shell | Bromobutyl rubber |
| Secondary material | PP flip tab - colour customisable | n/a |
| Hardness | n/a | 40–55 Shore A |
| Performance | ||
| Seal type | Crimp compression seal | Hermetic elastomeric seal |
| Self-sealing | n/a (holds stopper) | Yes - post-puncture ★ |
| Sterilization | Autoclave compatible | Autoclave compatible |
| Compliance & colour | ||
| Standard | ISO 8362 closure ref. | USP <381> · ISO 8362-5 |
| Colour options | 12+ standard · custom available | Grey (standard) |
| Sample | Free sample on request | Free sample on request |
| Standard MOQ | 5,000 sets (indicative) | Supplied as pair with cap |
who orders this cap and stopper pair
20mm flip off cap with rubber stopper - across the pharmaceutical and research supply chain
The 20mm flip off cap with matched rubber stopper is the most widely used pharmaceutical vial closure size - specified across virtually every injectable drug format in this volume range.
Pharmaceutical injectable manufacturers
Antibiotics · analgesics · hormones
The 20mm flip off cap and stopper is the standard closure for 5ml–20ml injectable drug products - the most common vial sizes in pharmaceutical injectable manufacturing worldwide.
Biotech & biologic producers
Protein injectables · lyophilized mAb
Biotech producers filling biologics and lyophilized proteins in 10ml–20ml vials requiring the 20mm cap and matched low-extractable stopper for regulatory submission.
Compounding pharmacies
Sterile compounding · small batches
Compounding pharmacies preparing sterile injectable formulations in 10ml–20ml vials, needing matched cap and stopper pairs with USP <381> documentation.
CDMOs & fill-finish
Multi-client production · high volume
Contract fill-finish organisations sourcing 20mm cap and stopper pairs in bulk for multiple client product lines across liquid and lyophilized injectable formats.
Research laboratories
Custom formulation · small scale
Research and development laboratories packaging experimental injectable formulations in vials for in vivo studies, needing pharmaceutical-grade closures in smaller quantities.
Packaging distributors
B2B stock · coloured cap range
Pharmaceutical packaging distributors stocking the full colour range of 20mm flip off caps with matched stoppers for downstream pharmaceutical manufacturer customers.
Right cap. Right stopper. Right colour. Right fit.
20mm flip off cap with rubber stopper - pre-matched, ready to crimp.
Tell us your required colour, stopper grade, and quantity - we'll confirm availability, pricing, and lead time, and arrange a free sample within 48 hours.
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